Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Abstract:This paper contends that rationality is more properly evaluated as a property of an organization’s relationships with its stakeholders than of the organization itself. We predicate our approach on the observation that stakeholders can hold goals quite distinct from those of owners and top managers, and these too can be rationally pursued. We build upon stakeholder theory and Weber’s classic distinction betweenwertrationalitatandzweckrationalitat, adding to them the “new institutionalist” concept of the organization field (1983, 1991). Stakeholders employ a variety of direct (...) and indirect mechanisms to rationalize relations with the firm. We discuss four: internal subunits, legislated stakeholder participation, legislated access to information, and direct stakeholder activism. These developments are blurring the distinction between the environment and the organization by importing the values and goals of external stakeholders into the internal organization. They are also precipitating a more structured set of relationships among the actors who comprise the field. To the extent that thezweckrationalitatvalues of managers and owners as well as thewertrationalitatconcerns of stakeholders are met, the firm is more rational. (shrink)

This paper explores possible connections between gender and the willingness to engage in unethical business behavior. Two approaches to gender and ethics are presented: the structural approach and the socialization approach. Data from a sample of 213 business school students reveal that men are more than two times as likely as women to engage in actions regarded as unethical but it is also important to note that relatively few would engage in any of these actions with the exception of buying (...) stock with inside information. Fifty percent of the males were willing to buy stock with insider information. Overall, the results support the gender socialization approach. (shrink)

Peirce’s doctrine of God has scarcely been studied at all. This is surprising because his own naturally religious temperament, his desire for philosophical completeness and the influence of Kant, all led him to give an important place to theistic speculation in his philosophy. It is true that few parts of his philosophy reveal more than the fragmentary and unfinished nature of his thinking. This however does not take away from its importance both for the interpretation of his philosophy and for (...) the evaluation of its contribution. In this paper I want to examine his doctrine of God mainly in order to discover and outline what views he held in the matter. Such examination is an essential preliminary to any consideration of the value of his theistic thinking. Moreover, an objective exposition is already the best beginning of evaluation. However it is impossible to undertake this kind of examination without a careful search into various corners of his writings and a meticulous and slightly laboured presentation of one’s findings. But I think that the patience involved in such research has a rich reward. (shrink)

Inflammatory responses are essential for the clearance of pathogens and the repair of injured tissues; however, if these responses are not properly controlled chronic inflammation can occur. Chronic inflammation is now recognized as a contributing factor to many age‐associated diseases including metabolic disorders, arthritis, neurodegeneration, and cardiovascular disease. Due to the connection between chronic inflammation and these diseases, it is essential to understand underlying mechanisms behind this process. In this review, factors that contribute to chronic inflammation are discussed. Further, we (...) emphasize the emerging roles of microRNAs (miRNAs) and other noncoding RNAs (ncRNA) in regulating chronic inflammatory states, making them important future diagnostic markers and therapeutic targets. Copyright Line: © 2015 The Authors BioEssays Published by Wiley‐VCH Verlag GmbH & Co. KGaA. (shrink)

We discuss the profound influence which the Wigner distribution function has had in many areas of physics during its fifty years of existence.

“... it ain't likely to have a radius of exactly zero,” is the conclusion of H. G. Dehmelt(1) from his Nobel Prize (1989) winning observations on trapped electrons. There are small discrepancies between Dehmelt's observations and the theoretical predictions of quantum electrodynamics (QED), which assumes that the electron is a point particle. Here we present evidence in support of Dehmelt's contention that the electron has a structure. Essentially, we point out that the nonrelativistic limit of QED is at variance with (...) a fundamental principle underlying all of physics, viz. the second law of thermodynamics. (shrink)

What was the background to Newman’s rectorship of the Catholic University in Dublin? In 1845 the British government proposed to establish three non-denominational colleges in Ireland; some of the Irish bishops felt that it would be possible to work out a modus vivendi with the government. A slight majority of the bishops, however, opposed these so-called “godless” colleges and voted at the Synod of Thurles in 1850, to found a Catholic University in Ireland—a country that had been repeatedly decimated by (...) poverty and oppression, and a few years earlier the potato famine (1845-48). (shrink)

A narrative history of Oxford Movement, whereby a group of Anglican intellectuals, notably Newman, Pusey, Keble and Froude, attempted to restore to the Victorian Church of England the character of primitive Christianity. Many of the inherent principles, such as Apostolic Succession, were seen to be exemplified by the Catholic Church.

The phase space formulation of quantum mechanics is based on the use of quasidistribution functions. This technique was pioneered by Wigner, whose distribution function is perhaps the most commonly used of the large variety that we find discussed in the literature. Here we address the question of how one can obtain distribution functions and hence do quantum mechanics without the use of wave functions.

In 50 B.C. Cicero writes to Atticus as follows : ‘Brundisium uenimus VII Kalend. Decembr. usi tua felicitate nauigandi; ita belle nobis flauit ab Epiro lenissimus Onchesmites. hunc si cui boles pro tuo uendito.’ The antonomasia, the euphonic sibilance, and the mannered rhythm are all prominent in Cicero's hexameter. The line is a humorously concocted example of affected and Grecizing narrative. But it is also a line which, Atticus is to suppose, would value; presumably therefore it is meant to hit (...) off characteristics of their style. Cicero must in fact be parodying what he regards as a typical ‘neoteric’ line, and the significance of this simple fact has perhaps been underestimated. (shrink)

The Romans had various ways of justifying their imperial aims and methods, some high-minded, some less so. We find in particular that they could give honourable and satisfying explanations of their aims and methods in war. Here for example is Cicero: quare suscipienda quidem bella sunt ob earn causam, ut sine iniuria in pace uiuatur; parta autem uictoria conseruandi ii, qui non crudeles in bello, non immanes fuerunt, ut maiores nostri Tusculanos, Aequos…in ciuitatem etiam acceperunt, at Carthaginem…funditus sustulerunt…mea quidem sententia (...) paci, quae nihil habitura sit insidiarum, semper est consulendum. et cum iis, quos ui deuiceris, consulendum est, tum ii qui armis positis and imperatorum fidem confugient, quamuis murum aries percusserit, recipiendi. (shrink)

In this paper I shall be examining the nature and provenance of what many people state or imply to be a traditional, conventional, even trite figure of speech: the Augustan Elegists' figure of the ‘seruitium amoris’’. It is indeed a very frequent image in the Elegists. As. F. O. Copley says: ‘Of all the figures used by the Roman elegists, probably none is quite so familiar as that of the lover as slave.’’ But frequency does not equal triteness nor traditionality.

The most popular emendation has been Heinsius's somnia sunt. I find the tone of this misplaced. Thepoet has since 66 laboriously catalogued variant aetiologies of Scylla monstrum. It is inappropriate that he should immediately follow this with the statement that all of them were ‘fancy’ or ‘nonsense’. For a start, we may note that the summation quidquid et ut quisque … presumably includes the version of Homer, to whose authority the poet had appealed in the case of the erroneous contamination (...) of the two Scyllas. Next, I suppose that if Scylla monstrum had been the subject of his poem, the poet might have wanted to say that some of the versions were wrong—or at least of less good authority, or less attractive than others for one reason or another. But Scylla monstrum is not the subject of his poem. He confutes, because it is his concern, the contamination; the listing of the rest, variants in a story not his subject, issues largely from an ‘Alexandrian’ delight in such learned display. It calls for no estimation of their lightness or wrongness: neither relative to one another—and certainly not absolutely. (shrink)

In one form or another an elevated, pleasure-transcending view of love is common, we might say natural. For readers of Latin poetry Catullus is perhaps the most impressive spokesman. In many respects, of course, Catullus is special. His particular values and choice of terminology, in his time and situation, mark him out from his crowd; in the Roman world indeed, ‘whole love’, perhaps rather its utterance, is hard to document before him. But a belief that love is powerful and profound, (...) an important if not the most important thing in life, this is not a rarity. Roman tombstones attest to love and devotion, and myths inherited from Greece enshrine love's power, endurance, and transcendence. (shrink)

In one form or another an elevated, pleasure-transcending view of love is common, we might say natural. For readers of Latin poetry Catullus is perhaps the most impressive spokesman. In many respects, of course, Catullus is special. His particular values and choice of terminology, in his time and situation, mark him out from his crowd; in the Roman world indeed, ‘whole love’, perhaps rather its utterance, is hard to document before him. But a belief that love is powerful and profound, (...) an important if not the most important thing in life, this is not a rarity. Roman tombstones attest to love and devotion, and myths inherited from Greece enshrine love's power, endurance, and transcendence. (shrink)

Once we have accepted that the Ciris stems from neither Virgil nor Gallus, but was written by a post-Virgilian poetaster, the obvious task for us is to try and formulate some more specific idea of the date of the poem. I think that it has been sufficiently proved that the Ciris is not only post-Virgilian, but post-Ovidian in origin, including as it does unquestionable imitations of that author. But this, to date, is really as far as we have got. It (...) is the purpose of this paper to put forward the thesis that the author of the Ciris lived late enough to know and be influenced by Statius and other poets of the later first century A.D. Now of course any theory that the Ciris knew and used Statius and other Silver poets is rendered highly unlikely if it can be maintained that Suetonius considered it, with the other minora, a genuine Virgilian work. And so we are brought back again to the famous list in the Donatan Life: deinde Catalepton et Priapea et Epigrammata et Diras, item Cirim et Culicem, cum esset annorum XXVI. cuius materia talis est. pastor fatigatur aestu; cum sub arbore condormisset et serpens ad eum proreperet, e palude culex provolavit atque inter duo tempora aculeum fixit pastori. at ille continuo culicem contrivit et serpentem interemit ac sepulchrum culici statuit et distichon fecit. (shrink)

Once we have accepted that theCirisstems from neither Virgil nor Gallus, but was written by a post-Virgilian poetaster, the obvious task for us is to try and formulate some more specific idea of the date of the poem. I think that it has been sufficiently proved that theCirisis not only post-Virgilian, but post-Ovidian in origin, including as it does unquestionable imitations of that author. But this, to date, is really as far as we have got. It is the purpose of (...) this paper to put forward the thesis that the author of theCirislived late enough to know and be influenced by Statius and other poets of the later first century A.D.Now of course any theory that theCirisknew and used Statius and other Silver poets is rendered highly unlikely if it can be maintained that Suetonius considered it, with the otherminora, a genuine Virgilian work. And so we are brought back again to the famous list in the DonatanLife:deinde Catalepton et Priapea et Epigrammata et Diras, item Cirim et Culicem, cum esset annorum XXVI. cuius materia talis est. pastor fatigatur aestu; cum sub arbore condormisset et serpens ad eum proreperet, e palude culex provolavit atque inter duo tempora aculeum fixit pastori. at ille continuo culicem contrivit et serpentem interemit ac sepulchrum culici statuit et distichon fecit. (shrink)

Connecting influence and leadership, the professor of business ethics assumes a sacred moral vocation. Directed towards the student's role in the marketplace, the business ethics course enjoins consideration of the values of social responsibility for the human community in its political, economic, and familial manifestations.

Bioethics today has become a subject of wide public concern. Almost every one of its tenets is being seriously questioned and likely to be reformulated. Moreover, the pressure on bioethics continues to mount as the number of moral conflicts that buffet our society increases. What, then, will bioethics look like a decade from now? In the variety of approaches that have been employed in the practice of bioethics, one has dominated in the United States in the last decade and a (...) half. That approach is "principlism", the use of moral principles to address theoretical issues and to resolve conflicts at the bedside. Recently, however, bioethicists and others increasingly have realized the limitations of principlism and are calling for the development of alternative approaches such as phenomenology, hermeneutics, narrative ethics, casuistry, and virtue ethics. This book maps the debate over principlism and the future direction of U.S. bioethics. Part One consists of a sociological description of U.S. bioethics at the beginning of the 1990s, along with a defense of principlism by one of its major proponents. Part Two maps cross-cultural critiques of principlism, while Part Three covers five alternatives to it. Three essays in Part Four - by a bioethicist, a physician, and a theologian - reflect on the future of U.S. bioethics, principlism, and its alternatives. The Afterword emphasizes the place of religion and theological discourse in the alternative approaches and in the future of bioethics. (shrink)